Pathogenesis of COPD

Pathologic changes in chronic obstructive pulmonary disease (COPD) happen in the large (central) airway routes, the little (peripheral) bronchioles, and the lung parenchyma. Most instances of COPD are the consequence of introduction to noxious stimuli,, regularly tobacco smoke. The normal inflammatory response is enhanced in people inclined to COPD advancement. Increased quantities of activated polymorphonuclear leukocytes and macrophages discharge elastases in a way that can't be neutralized viably by antiproteases, bringing about lung destruction.

  • Chronic bronchitis
  • Emphysema
  • Refractory asthma

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