Mohammad Hossein Boskabady
Professor
Applied Physiology Research Centre and Dept. of Physiology
Mashhad University of Medical Sciences
Mashhad IR
Iran
Title: Therapeutic potential for COPD treatment, evidence for stem cell and natural product therapy
Biography
Biography: Mohammad Hossein Boskabady
Abstract
In a series of studies various possible therapeutic potential of natural product and stem cell for treatment of COPD were examined. The effect of adipose derived stromal cells (ASCs) on tracheal responsiveness, interleukin-8 (IL-8), total and differential white blood cells (WBC) counts in animal model of COPD was shown. The effect of ASCs on lung histopathologic changes and serum level of malondialdehyde (MDA) in COPD animals was also demonstrated in another study. The effect of Zataria multiflora and its constituent, carvacrol on systemic inflammation including serum levels of IL-8 and MDA as well as total and differential white blood cell (WBC) in the blood of guinea pig COPD model was documented in two studies. The preventive effect of Zataria multiflora and carvacrol on thiol groups, IL-8, total and differential WBC broncho-alveolar lavage fluid (BALF), lung pathology and tracheal responsiveness, were also demonstrated. Tracheal responsiveness to both methacholine and ovalbumin reduced in COPD animal model due to Nigella sativa extract and vitamin C treatment. The preventive effect of vitamine E, dexamethazone and the extract of Nigella sativa on tracheal responsiveness and lung inflammation of sulfur mustard exposed animals was studied. Significant improvement in pulmonary function tests and respiratory symptoms in chemical war victims treated with the extract of Nigella sativa for two month was also observed. The results of these studies indicated a promising therapeutic potential for stem cell and natural product in the treatment of COPD which should be clinically evaluated in further